Biological aging is directly impacted by physiological integrity. Muscle strength, mass, function, quantity, and quality loss are some of the main issues associated with the process of aging. As we age the performance of our muscle cells decline which leads to a weakened immune system, sarcopenia, obesity, and chronic disease among much more. Healthgevity has selected PeptiStrong™, Senactiv® and AstraGin® which are all clinically proven ingredients to put your muscles in the best position to thrive regardless of your age.

In a recent study it was concluded that lower muscle strength in late adolescence showed direct connection with higher risk of chronic disease. As such, skeletal muscle might be the central integrator between sarcopenia, obesity, immune senescence and more in an aging biological system. Preserving muscle mass is critical for optimizing health span. Research shows the strongest one-third of the population over the age of 60 has a 50% lower death rate than the weakest, making muscle a key predictor of longevity. Recent discoveries of clinically proven ‘growth promoting’ ingredients have made the process of building and preserving muscle more obtainable.

PeptiStrong™, Senactiv® and AstraGin® work synergistically to target multiple mechanisms, to provide a wide range of benefits in muscle health.

PeptiStrong™ (Peptides from hydrolyzed fava bean protein)

Through cutting edge Al-precision technology, Nuritas is creating a brand-new category of precision peptide ingredients from nature. Their cell-signaling power helps the body function at its best. Longevity is the first product resulting from Healthgevity's collaboration with Nuritas and contains PeptiStrong™ : precision peptides that have been clinically proven to support muscle health. PeptiStrong™ can increase muscle synthesis by supporting mTOR, reduce muscle loss by downregulating muscle atrophy related genes and improve muscle health by reducing inflammation properties.

Backed by two peer-reviewed clinical studies, this plant-based intelligent ingredient has outperformed animal protein. It has a multi-dimensional effect on muscle health: promoting muscle strength, improving recovery after intense exercise, boosting energy, and supporting the synthesis of protein that assists in maintaining and building muscle. A 'peptide-specific’ effect to address the muscle homeostasis between muscle protein synthesis, muscle atrophy and inflammation, offers an alternative to a purely uncharacterized nutritional intervention. In the most recent double blind placebo clinical study, PeptiStrong™ alone provided:

Featured PeptiStrong™ research benefits:

• Regenerates muscles by increasing the expression of new muscle fibers.
• Type I “Slow Twitch” Muscle Fibers are responsible for endurance and strength endurance. They contain a higher number of mitochondria and utilize fat for energy.
• Type II “Fast Twitch” Muscle fibers are responsible for strength and force production. Loss of Type II fibers is most associated with aging.
• Reduces muscle loss and fat accumulation
• Reduces Tumor Necrosis Factor-alpha (TNF-α)
• Improves cellular metabolism through the activation of AMPK which in turn increases the levels of NAD+ and sirtuins
• Maintains autophagy in skeletal muscle similar to fasting
• Induces mitochondrial biogenesis in the muscle cell

The powerful combination of TeaCrine®, Dynamine®, RhodioPrime 6x®, InnovaTea®, Asian ginseng and huperzine A help to increase energy levels, cognitive function, motivation, and focus all while reducing fatigue. Mindset may also aid in the prevention of age-related cognitive decline and has neuroprotective properties without the jitters or crash. We have now discovered certain ingredients included in Mindset that have shown positive changes in brain wave activity specifically delta and theta waves which are associated with focus and decision making under pressure. Mindset also features the enhancement of caffeine (increased half-life), and the activation of dopamine receptors are some of the mechanisms by which the ingredients are working, making it the ideal formula to utilize whenever needing a desired edge.

TeaCrine® is a trademarked form of a purine alkaloid extracted from kucha tea leaves, called theacrine. Several studies show that TeaCrine® is effective at increasing energy levels, mood, physical performance, and cognitive function.

Dynamine® is methylliberine, a derivative of caffeine and relative of theacrine and is faster-acting, harder-hitting in its ability to increase mental energy, alertness and focus. Dynamine® and TeaCrine® both serve a methylurates, a rare class of bioactive ingredients that are neuro-activating yet does not affect heart rate, blood pressure, or vasoconstriction (pressor response). So, they stimulate the Central Nervous System, but not the cardiovascular system.

InnovaTea® High Purity Natural Caffeine is a unique, naturally derived source of caffeine extracted from fermented Camellia sinensis (tea leaves). The tea leaves used to produce InnovaTea® are grown by farmers who utilize sustainable farming practices to help reduce environmental impact. The leaves are also fully traceable back to the farms where they are grown. InnovaTea® is an excellent, clean label alternative to chemically synthesized caffeine.

Ground-breaking research showed “C3X” (caffeine + Dynamine® + TeaCrine®) boosts caffeine’s half-life 300%, so your energy, mood and focus last 300% longer. When dosing Dynamine® and TeaCrine® alongside caffeine, you can get a much longer-lasting energy boost (3x) than you would using the same amount of caffeine alone. Dynamine® and TeaCrine® activate delta and theta brain waves, which are associated with focus and decision making under pressure. Dynamine® and TeaCrine® also active dopamine receptors, help preserve dopaminergic neurons, extend the half-life of caffeine, and do so without the crash or jitters that can come from caffeine-alone.

RhodioPrime 6X® is rhodiola which features a market-leading high 6% salidroside extract, which is 6X the potency of the majority of other rhodiola's on the market. Salidroside is the most bioactive constituent in rhodiola and thought to be responsible for its health-promoting effects. As an adaptogen, rhodiola helps the body resist biological stress. Since stress impacts everything, rhodiola can yield many benefits, such as enhanced mood, endurance, energy, and cognitive function. Studies show that salidroside has various biological effects, providing support for the cardiovascular system, nervous system, liver, and cognition. Its supportive benefits also include providing support for a healthy mood and feelings of well-being, healthy antioxidant status, healthy circulation and oxygenation, anti-aging and vibrant energy levels.

Mindset is all about the energy and performance when you need it most. TeaCrine®, Dynamine® and RhodioPrime 6x have all been shown to improve focus and mental clarity, while InnovaTea® has been shown to increase energy levels and reduce fatigue. Asian ginseng and huperzine A help support healthy brain function and cognitive performance.

Cellular senescence is a hallmark of aging, it is a permanent state of cell cycle arrest induced by cellular stresses. This has numerous implications for the body, including its ability to adapt to changes in its environment, as well as its capacity to regenerate itself. This can be beneficial for individuals to understand how cellular senescence works and what the potential benefits are for the body. Firstly, understanding cellular senescence can help us better understand aging, as this process is a major contributor to the aging process. Additionally, it can also provide insight into certain diseases and conditions that may be linked to the inability of cells to divide and proliferate properly. Finally, by targeting cellular senescence, we may be able to find new ways of fighting against aging and diseases associated with it. Thus, understanding ways to best support cellular senescence can be a powerful tool in our pursuit of longevity and improved health span. Senolytics, are small molecules that can selectively kill senescence cells and have been developed to support various age-related diseases while also extending healthspan. In recent years, emerging natural compounds have been discovered to be effective senolytic agents that are featured in this breakthrough formula. Clearance of senescent cells can support the reduction of inflammation, decrease macromolecular dysregulation, and enhance function of stem and progenitor cells.

Rejuvenate 2.0 presents a unique solution for intervention through two mechanisms:

(1) eliminating senescent cells (senolytics)

(2) inhibiting of senescent- associated secretory phenotype (SASP)

Featured benefits:

• Once weekly pulsed high dosing blend of senolytics which have been shown to reduce senescent cells in vivo.
• Targets aging at the cellular level
• Induces autophagy to promote intracellular recycling and cellular renewal
• Reduce full body features of Senescence-Associated Secretory Phenotype (SASP).
• Protects cells against free radicals and oxidative stress
• Targets inflammaging at the cellular level and supports a healthy inflammatory response
• Supports a healthy immune system
• Formula designed to also treat muscle senescence.
• Exercises muscles longer and harder with a boost in citrate synthase activity.
• Recovers more effectively with a reduction in inflammation biomarkers.
• Decreases SA-β-Gal by 63% in muscle tissue.

Fisetin:

Fisetin is a polyphenol found in many fruits and vegetables, including strawberries, apples, and onions. It has been studied for its potential benefits related to aging. Fisetin has shown great promise to inhibit senescence due to its ability to act on numerous biological processes. Studies have shown that fisetin is the most natural senolytic agent that can protect cells from oxidative damage, protecting them against age related diseases and reduce senescence markers in multiple tissues.

Quercetin Phytosome:

Quercetin is one of the most studied dietary flavonoids ubiquitously present in various vegetables. A key feature of quercetin is its strong antioxidant activity which potentially enables it to quench free radicals from forming resonance-stabilized phenoxyl radicals. However, chemical instability, poor water solubility and low bioavailability of quercetin greatly limit its applications which is why a phytosome technology is the preferred delivery system to overcome these limitations. This enhanced form of quercetin has been shown to be 20 times better absorbed than other quercetin options.

Prime Gut Health was created because the digestive system is the foundation of getting and staying healthy. There are many benefits to an optimal digestive system such as a healthy immune system and the protection against harmful viruses, bacteria, fungi, and yeast. The ingredients selected in Prime Gut Health work together to help restore gut homeostasis and GI barrier function.

There are many benefits to taking Prime Gut Health, including:

• Supports healthy GI barrier function*
• Helps restore gut homeostasis*
• Binds and neutralizes bacterial toxins in the gut*
• Promotes a healthy immune system and respiratory health*
• Supports digestive health and gut discomfort*
• Increased nutrient absorption*
• Supports gut inflammation especially within the intestinal wall*
• Promotes a healthier GI environment*
• Promoted regularity and healthy bowel function*

 WHAT MAKES PRIME GUT HEALTH SO IMPACTFUL?

ImmunoLin® is the branded ingredient serum-derived bovine immunoglobulin/protein isolate (SBI) with over 40 human studies demonstrating its clinical efficacy in digestive and immune health. SBI has been shown to be a broad-spectrum modulator of the immune system by targeting excessive or imbalanced immunity.* In addition, ImmunoLin® works by binding, neutralizing, and removing pathogenic bacteria, viruses, and other gut irritants that can lead to inflammation.* It also helps to repair the gut lining and restore gut homeostasis.*

Aging is characterized by an increase in the concentration of inflammatory markers in the blood- stream, a phenomenon that has been termed “inflammaging”. The inflammatory response is beneficial as an acute, transient reaction to harmful conditions, facilitating the defense, repair, turnover and adaptation of many tissues. However, chronic and low-grade inflammation is likely to be detrimental for many tissues and for normal functions. Our team investigated various natural solutions targeting multiple influences of inflammaging. Resolve+ contains numerous compounds that have been found to reduce the inflammatory response by targeting a variety of mechanisms.

Acmella oleracea (“jambu”) is sourced from Sardinia, Italy and rich in alkylamides mainly represented by spilanthol. Its flowers are widely used in folk medicine to treat toothache due to tingling, numbness, and local anesthesia caused in the mouth. Acmella oleracea has been shown to be active in fatty acid amide hydrolase (FAAH) inhibition the enzyme responsible for the degradation of fatty acid amides and cannabinoid type 2 (CB2) activation. There are almost 100 studies suggesting the supportive potential for anti-inflammatory, antioxidant, and analgesic effects of Acmella. Studies reported in this review confirmed activities of Acmella, postulating that transcription factors of the nuclear factor-κB family (NF-κB) trigger the transcription iNOS and COX-2 and several other pro-inflammatory mediators, such as IL-6, IL-1β, and TNF-α.

As the science of longevity continues to evolve, more and more researchers are focusing on geroprotectors- compounds capable to have the potential to prevent or even reverse aging at the cellular level. Telomere Prime reflects cutting-edge science, featuring a broad spectrum of ingredients that have been shown to support healthy cellular function. The health of our cells is foundational to our overall health, so supporting our health and vitality is one of the smartest things we can do for our long-term wellbeing. The compounds in Telomere Prime have been carefully chosen for their ability to protect and repair DNA, reduce telomere shortening and support healthy cellular function. Telomere Prime supports genomic stability and other key indicators of healthspan and lifespan such as, antioxidant protection, body global cell health, inflammation support, and mitochondrial function.

Featured Benefits:

• Support the body’s natural ability to repair its own DNA.
• Significantly increases telomere length in yearlong clinical trials.
• Inhibit synthesis of pro-inflammatory “inflammaging” cytokines such as interleukin (IL)-6, (IL)-8, NF-KB and TNF-alpha.
• Prevent cell death through inhibition of the pro-apoptotic factors.
• Support your DNA’s defenses against free radical damage and activates NRF2
• Activates the cell and mitochondrial renewal process
• Chelate divalent metal ions.
• Protect against damage caused by the prooxidants ferric-NTA and β-amyloid.
• Enhance the immune system by increasing the life cycle of white blood cells.
• Helps reduce DNA and mitochondrial damage and protect against free radicals.
• Protect against UV and gamma radiation by neutralizing radiation-induced reactive oxygen species (ROS).